Homozygous beta thalassaemia in Liberia.

The haemoglobin pattern of sickle cell and haemoglobin C beta +-thalassaemia in Liberia.

Haemoglobin components in 21 Liberians with Hb S beta +-thalassaemia and four with Hb C beta +-thalassaemia were measured to classify the forms of beta +-thalassaemia present in the population. In 20 Hb S and all Hb C beta +-thalassaemics the data were consistent with the interaction of these variants with the mild type 2 (Negro) form of beta +-thalassaemia. The data available were insufficient...

Homozygous Thalassaemia in an English Child.

During the past few years there have been several reports of thalassaemia occurring in English families (Garrett and Morton, 1960; Callender, Mallett, and Lehmann, 1961; Josse, 1962; Roberts, 1963). All the cases, however, have been of the heterozygous form of the disease (thalassaemia minor and thalassaemia trait). This paper reports the case of an English child with homozygous thalassaemia (t...

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

Serum IgM, IgA, and IgG concentrations were measured in 19 patients suffering from blood-dependent homozygous beta-thalassaemia. The study was prospective and the same patients served as presplenectomy controls. IgG levels rose rapidly and continuously after splenectomy IgA levels also rose but not so sharply. IgM fell to low levelr pattern was found in the cross-sectional part of the study com...

Screening for beta thalassaemia

Binding of serum ferritin to concanavalin A: patients with homozygous beta thalassaemia and transfusional iron overload.

Serum ferritin concentrations have been measured in 124 patients with homozygous beta thalassaemia who were between 2 and 21 years old, had received 11--504 units of blood but had not undergone splenectomy. There were highly significant correlations between serum ferritin concentration and both the amount of blood transfused and alanine amino-transferase (ALT) activity. However, multivariate an...